APIs Hydroxyethyl Starch, HES 130/0.4, HES 200/0.5, plasma volume expander, pharmaceutical API, cell culture supplement, serum-free media

Chemical Profile and Versatility

Hydroxyethyl Starch (HES) 130/0.4 and 200/0.5 are high-purity, modified natural polymers characterized by their mean molecular weight and degree of substitution. These parameters critically influence their colloid osmotic pressure and in vivo retention time -4. As a cGMP-compliant Active Pharmaceutical Ingredient (API), they serve as first-line colloid volume expanders for infusion solutions to treat and prevent hypovolemia -7. Furthermore, their high biocompatibility makes them excellent candidates for advanced cell culture media formulations.

Key Applications and Uses

Pharmaceutical Formulations: Used as a core API in infusion solutions for volume replacement therapy in surgical, trauma, and burn patients -4-7. They are also employed in acute normovolemic hemodilution (ANH) to reduce the need for allogeneic blood transfusion -7.

Biomedical Research & Cell Culture: Emerging as a valuable, serum-free supplement in specialized cell culture media. Studies show that HES 130/0.4 can be well-tolerated and support superior cell survival in sensitive models like corneal organ culture, outperforming other agents like dextran -8. Its properties are also leveraged in cryopreservation protocols.

Nanotechnology & Drug Delivery: HES serves as a superior biocompatible coating for nanoparticles, such as iron oxide nanoparticles (IONPs), enhancing their stability and safety for vascular-targeted applications without inducing cytotoxicity or inflammation -3.

Our Quality Commitment

Supplied as a white to off-white powder -1-10, our HES is manufactured under strict quality controls. We provide comprehensive support documentation and ensure our products meet the demanding requirements of both pharmaceutical manufacturing and cutting-edge bioprocessing.