Intermediates 6-bromo-3-iodo-1H-indazole for critical molecular building block

CAS Number: 885521-88-0 

Molecular Formula: C₇H₄BrIN₂

Molecular Weight: 322.93 g/mol

Introduction:

6-Bromo-3-iodo-1H-indazole is a premium, bifunctionalized heteroaromatic compound meticulously manufactured for demanding applications in medicinal chemistry and drug development. As a key molecular building block, it provides researchers with a strategic starting point for the efficient synthesis of complex and diverse chemical entities.

Key Features & Benefits:

Dual Halogen Functionality: The presence of both bromine and iodine atoms on the robust indazole scaffold allows for selective and sequential palladium-catalyzed cross-coupling reactions. This enables precise, step-wise diversification of the molecule, a critical capability in Structure-Activity Relationship (SAR) studies.

Synergistic Reactivity: The iodine at the 3-position is typically more reactive in cross-couplings, allowing for initial functionalization. The bromine at the 6-position can then be used in a subsequent, orthogonal coupling step. This controlled reactivity streamlines the synthesis of complex target molecules.

High-Purity & Reliability: We ensure every batch meets the highest standards of purity (typically >95% by HPLC), confirmed by rigorous QC protocols including NMR and Mass Spectrometry. This guarantees reliable and reproducible results in your most critical experiments.

Strategic Application: This building block is ideally suited for constructing focused libraries for high-throughput screening, particularly in the development of targeted therapies such as protein kinase inhibitors, oncology agents, and CNS drugs.

Ordering Information:

Available in quantities from milligrams to multi-grams. Contact our sales team for custom synthesis and bulk pricing. Data sheets and COA available upon request.